Solvate form M of trametinib dimethyl sulfoxide and methods of making and using thereof
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United States of America Patent
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Nov 10, 2015
Grant Date -
Jun 4, 2015
app pub date -
Jun 30, 2014
filing date -
Dec 3, 2013
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Abstract
The present invention relates to a crystalline Form M of trametinib dimethyl sulfoxide solvate. Comparing with the prior art, Form M is a more stable crystalline form with better particle size distribution and good flowability and is non-hygroscopic. Therefore, it is more suitable for formulation. The present invention also relates to pharmaceutical compositions thereof, methods of making and using thereof. Trametinib dimethyl sulfoxide solvate has a structure as shown below:
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