Inhibitors of glutaminyl cyclase
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United States of America Patent
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Nov 10, 2015
Grant Date -
Sep 15, 2011
app pub date -
Mar 3, 2011
filing date -
Mar 3, 2010
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Abstract
The invention relates to novel heterocyclic derivatives as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.
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