Additive for the crystallization of proteins, use and process

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United States of America Patent

PATENT NO 9180386
APP PUB NO 20120123088A1
SERIAL NO

13263032

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Abstract

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The present invention relates to the use and to a process involving at least one calix[n]arene derivative substituted by at least one acid functional group on the upper face and at least one aliphatic chain of variable length on the other face, as an additive for crystallization of a polar and/or positively charged molecule. The use and the process of the present invention have the advantage of enabling, facilitating and/or accelerating the crystallization of polar and/or positively charged molecules, especially of membrane proteins that are in solution or soluble, which had previously proved to be very difficult.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITE CLAUDE BERNARD LYON 143 BOULEVARD DU 11 NOVEMBRE 1918 LYON 69622
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -3 RUE MICHEL ANGE PARIS 75016

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Coleman, Anthony W Caluire, FR 2 4
Falson, Pierre G Annonay, FR 1 1
Huche, Frederic La Ferte-Allais, FR 2 4
Leydier, Antoine Bagnols-sur-Ceze, FR 6 8
Merheb, Rachel Rima Matar Saint Genis Laral, FR 1 0

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