Serum-based, diagnostic, biological assay to predict pregnancy disorders
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United States of America Patent
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Nov 3, 2015
Grant Date -
Mar 10, 2011
app pub date -
Feb 4, 2009
filing date -
Feb 4, 2008
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Abstract
The invention provides serum-based, diagnostic, biological assays for predicting disorders of pregnancy resulting from poor trophoblast and/or placental ischemia, including preeclampsia. Serum samples from such subjects exhibit an ability to disrupt the architecture involving fetal trophoblasts and maternal endothelial cells in a three-dimensional, dual cell co-culture system provided herein, in contrast to normal pregnancy serum samples. Based on these distinctions, the assays are employed to predict pregnancy outcomes as early as first trimester.
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