Puro-DHFR quadrifunctional marker and its use in protein production
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United States of America Patent
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Nov 3, 2015
Grant Date -
Jan 22, 2015
app pub date -
Sep 10, 2014
filing date -
Jun 7, 2007
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Abstract
This invention relates to industrial production of proteins. More specifically, the invention relates to the res-DHFR surrogate marker, which corresponds to a fusion between DHFR and a protein conferring resistance to a toxic compound or conferring a metabolic advantage. The invention further relates to the use of res-DHFR for screening cells for high expression of a protein of interest. The invention is illustrated by the Puro-DHFR surrogate marker, which corresponds to a fusion between the puromycin N-acetyltransferase and dihydrofolate reductase (DHFR).
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