Anticancer fusion protein comprising trail and a growth factor receptor inhibitor
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United States of America Patent
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Nov 3, 2015
Grant Date -
Oct 31, 2013
app pub date -
Jan 5, 2012
filing date -
Jan 5, 2011
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Abstract
A fusion protein comprising domain (a) which is a functional fragment of hTRAIL protein sequence, which fragment begins with an amino acid at a position not lower than hTRAIL95, or a homolog of said functional fragment having at least 70% sequence identity; and domain (b) which is a sequence of an anti-angiogenic effector peptide, wherein the sequence of domain (b) is attached at the C-terminus or N-terminus of domain (a). The fusion protein can be used for the treatment of cancer diseases.
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