Mediators of hedgehog signaling pathways, compositions and uses related thereto
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United States of America Patent
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Nov 3, 2015
Grant Date -
Mar 31, 2011
app pub date -
Apr 28, 2010
filing date -
Sep 16, 1999
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Abstract
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.
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