3-(5-methyl-2-oxo-l, 3-dioxol-4-yl) methyloxy-2-trans-[(4-chloro phenyl) cyclohexyl][1,4]naphthaquinone-atovaquone prodrug

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United States of America Patent

PATENT NO 9169232
APP PUB NO 20140343297A1
SERIAL NO

14344644

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Abstract

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The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4-chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture.

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Patent Owner(s)

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ALKEM LABORATORIES LIMITEDMUMBAI 400013

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kanakamajalu, Shridhara Bangalore, IN 4 0
Kunjyannaya, Akshaya Bangalore, IN 1 0
Nagarajan, Kuppuswamy Bangalore, IN 9 10
Rao, Kothapalli Sundarraja Bangalore, IN 3 0
Saralaya, Sanjay Sukumar Bangalore, IN 1 0
Shashiprabha, null Bangalore, IN 3 0

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