Pimecrolimus foam composition containing hexylene glycol, optionally oleyl alcohol, dimethylisosorbide and/or medium chain triglycerides
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United States of America Patent
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Oct 27, 2015
Grant Date -
Jul 31, 2008
app pub date -
Apr 7, 2005
filing date -
Apr 8, 2004
priority date (Note) -
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Abstract
Pharmaceutical foam compositions substantially free of ethanol and comprising pimecrolimus in a carrier vehicle comprising a mixture of oily solvents amounting to at least 40% of the total weight of the composition and consisting of:
- i) hexylene glycol;ii) optionally oleyl alcohol; andiii) dimethylisosorbide and/or medium chain triglycerides;and additionally:iv) when oleyl alcohol is absent, water in an amount of less than 25%;v) at least one consistency agent;vi) at least one preservative; andvii) at least one surfactant/emulgator; and propellant gas for foaming;and optionally further conventional excipients.
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