Crystalline (6R,7R)-7-{2-(5-amino-[1,2,4] thiadiazol-3-yl)-2-[(Z)-trityloxyimino]-acetylamino}-3-[(R)-1′-tert-butoxycarbonyl-2-oxo-[1,3′]bipyrrolidinyl-(3E)-ylidenemethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester; its manufacture and use

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United States of America Patent

PATENT NO 9163034
APP PUB NO 20150005491A1
SERIAL NO

14486205

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Abstract

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A solid DMSO solvate of a compound of formula (I) is described, which is a useful intermediate for preparing the broad spectrum antibiotics Ceftobiprole and Ceftobiprole Medocaril.

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Patent Owner(s)

Patent OwnerAddress
BASILEA PHARMACEUTICA AG4058 BASEL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alpegiani,, Jr Marco Milan, IT 1 0
Cabri, Walter Rozzano, IT 98 224
Heubes, Markus Schopfheim, DE 9 3
Longoni, Davide Gorgonzola, IT 11 12
Schleimer, Michael Inzlingen, DE 3 0

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