Signal amplification microspheres, their use in one-step and multi-step analytical amplification procedures and methods for their production
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United States of America Patent
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Oct 6, 2015
Grant Date -
Jul 5, 2012
app pub date -
Jun 10, 2010
filing date -
Jun 10, 2009
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Abstract
The present invention relates to microspheres comprising protein signal precursor molecules, or a carrier protein bonded to signal precursor molecules, wherein said signal precursor molecules are activatable to generate a detectable signal whilst remaining bonded to the carrier protein. Also disclosed is a method of making such microspheres comprising the steps of mixing protein molecules with a matrix former in solution; adding a reducing reagent to the mixture; removing the reducing reagent; and removing the matrix former to leave microspheres of protein molecules. Also disclosed are bioassay methods using the microspheres to provide signal amplification, including an amplification cycling procedure.
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