Process for the preparation of nateglinide
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United States of America Patent
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Oct 6, 2015
Grant Date -
Jun 27, 2013
app pub date -
Jun 14, 2011
filing date -
Jun 14, 2010
priority date (Note) -
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Abstract
The present invention relates to a process for the preparation of substantially pure nateglinide of formula (I), substantially free from the cis-isomer and L-enantiomer and preparation of enantiomerically pure nateglinide form B, directly from the hydrolysis of a (−)-N-(trans-4-isopropylcyclohexyl-1-carbonyl)-D-phenylalanine alkyl ester in a ketonic solvent or water or mixture thereof.
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