Vaccination by circumventing preexistent immunity

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United States of America Patent

PATENT NO 9149508
SERIAL NO

13660035

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Abstract

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Methods and compositions are disclosed for improving vaccination in a subject with preexistent antibodies to the antigenic component of the immunizing vaccine. By temporarily sequestering, disabling, and/or suppressing preexistent antibodies and/or Fc-mediated mechanisms according to the various example embodiments, the target antigenic component of a vaccine has an increased opportunity to enter antigen-presenting cells through the same pathway that it would use in seronegative subjects. A balanced immune environment is thereby restored and B cells are properly activated to produce antigen-specific antibodies following vaccination.

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Patent Owner(s)

Patent OwnerAddress
SIGMOVIR BIOSYSTEMS INC9610 MEDICAL CENTER DRIVE SUITE 100 ROCKVILLE MD 20850

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blanco, Jorge C G Washington, US 3 0
Boukhvalova, Marina S Potomac, US 2 0

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