Sustained-release composition containing tetrahydropyrido[4,3-b]indole derivatives and preparation of the derivatives
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United States of America Patent
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Oct 6, 2015
Grant Date -
May 17, 2012
app pub date -
Mar 29, 2010
filing date -
Apr 10, 2009
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Abstract
The present invention relates to a sustained-release composition containing 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole or a pharmaceutically acceptable salt thereof as an active ingredient, preparation thereof and the compound. The composition is suitable for oral administration by one time per day, and achieves the peak plasma concentration at 1.0 to 3 hours after oral administration. The composition is suitable for manufacturing a medicament for treatment of cognitive dysfunction syndrome, Alzheimer's disease, Parkinson's disease, Huntington's disease, or senile dementia.
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