Fluorescent cyclic peptides, preparation method thereof and use of these peptides for measuring the enzymatic activity of a protease enzyme

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United States of America Patent

PATENT NO 9139862
APP PUB NO 20110256567A1
SERIAL NO

12737082

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Abstract

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The invention pertains to a cyclic peptide comprising the following sequence:

description='In-line Formulae' end='lead'-S1-X1-S2-X2-description='In-line Formulae' end='tail'

    wherein S1 is a first target peptide sequence of a protease enzyme E1, S2 is a second target peptide sequence of a protease enzyme E2, S1 and S2 possibly being the same or different, said first peptide sequence S1 and said second peptide sequence S2 comprising 4 to 14 amino acids, E1 and E2 possibly corresponding to the same protease enzyme or to two different protease enzymes, X1 is a probe carrying a fluorescent donor group and X2 is a probe carrying a fluorescent or non-fluorescent acceptor group.

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Patent Owner(s)

Patent OwnerAddress
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES75015 PARIS
UNIVERSITE VICTOR SEGALEN - BORDEAUX 2146 RUE LEON SAIGNAT 33076 BORDEAUX

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berthelot, Thomas Les Ulis, FR 23 98
Deleris, Gérard Bordeaux, FR 2 4

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