Tumor targeted drug combretastatin A4 derivative
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United States of America Patent
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Sep 22, 2015
Grant Date -
May 8, 2014
app pub date -
Jul 4, 2012
filing date -
Jul 5, 2011
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Abstract
The present invention relates to imidazole, oxazole and thiazole derivatives of tumor-targeted drug combretastatin A4, and phosphate esters, sulfonate esters or pharmaceutically acceptable salts, glycoside derivatives, solvates thereof, wherein the A-ring comprises a 3,5-dimethoxyphenyl group having a substituent at the 4-position. The pharmacological activity assays have demonstrated that the compounds of the present invention have good in vitro anti-tumor activity and excellent tubulin inhibitory effect.
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