Formulations for the treatment of diabetes
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United States of America Patent
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Sep 22, 2015
Grant Date -
Nov 27, 2014
app pub date -
Oct 31, 2012
filing date -
Oct 31, 2011
priority date (Note) -
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Abstract
Disclosed is a formulation for parenteral administration comprising insulin that comprises a pH memory between 1 to 4 or between 6 to 8 and an aprotic polar solvent, wherein the insulin is solubilized in the aprotic polar solvent, wherein the solubilized insulin comprises stable monomeric or dimeric forms of insulin or mixtures thereof, and wherein the water content of the formulation is equal to or less than 15% w/v.
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