Methods and compositions for treating and preventing malaria using an invasion ligand directed to a protease-resistant receptor
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United States of America Patent
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Sep 15, 2015
Grant Date -
Dec 22, 2011
app pub date -
Aug 27, 2009
filing date -
Aug 27, 2008
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Abstract
This invention relates to an immunogenic molecule comprising a contiguous amino acid sequence of an invasion ligand of a strain of Plasmodium falciparum, the invasion ligand capable of binding to an erythrocyte receptor, the receptor function being resistant to trypsin and neuraminidase and chymotrypsin, wherein when administered to a subject the molecule is capable of inducing an immune response to the strain. The invention further relates to compositions and methods for the treatment of diseases such as malaria.
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