vaccine
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United States of America Patent
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Sep 15, 2015
Grant Date -
Sep 6, 2012
app pub date -
Feb 13, 2012
filing date -
Mar 9, 2007
priority date (Note) -
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Abstract
The present invention is a live vaccine from a culture of cells of Haemophilus parasuis exhibiting attenuated pathogenicity and capable of triggering a protective immune response when administered to pigs. The cell culture was modified from a pathogenic parent strain by MNNG mutagenesis and was selected by complete dependence on streptomycin for growth. Several SNPs have been identified as associated with specific proteins that are associated with virulence as seen in the literature in H. parasuis or related bacterial species.
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