Sulfated depolymerized derivatives of exopolysaccharides (EPS) from mesophilic marine bacteria, method for preparing same, and uses thereof in tissue regeneration

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United States of America Patent

PATENT NO 9125883
APP PUB NO 20140037597A1
SERIAL NO

14052133

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Abstract

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The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerization of said native EPSs followed by a step of sulphating the resulting depolymerized derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg (m) g/ml.

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Patent Owner(s)

Patent OwnerAddress
INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER)92130 ISSY-LES-MOULINEAUX
UNIVERSITE RENE DESCARTES12 RUE DE L'ECOLE DE MEDECINE PARIS CEDEX 06 75270

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Colliec-Jouault, Sylvia Nantes, FR 15 23
Courtois, Anthony Saint Renan, FR 8 21
Fioretti, Florence Paris, FR 5 8
Godeau, Gaston-Jacques Antony, FR 8 11
Gueniche, Farida Rueil-Malmaison, FR 4 8
Guezennec, Jean Plouzane, FR 16 48
Raguenes, Gérard Locmaria Plouzane, FR 3 5
Ratiskol, Jacqueline Sainte Luce sur Loire, FR 8 13
Senni, Karim Aulnay-sous-Bois, FR 10 14
Sinquin, Corinne Nantes, FR 16 21
Yousfi, Myriam Paris, FR 4 8

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