Cellular libraries of peptide sequences (CLiPS) and methods of using the same
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United States of America Patent
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Sep 1, 2015
Grant Date -
May 16, 2013
app pub date -
Sep 28, 2012
filing date -
Aug 31, 2005
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Abstract
The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. In addition, the present invention also provides kits and methods for screening a library of cells presenting the candidate peptides in peptide display scaffolds to identify a ligand for an enzyme.
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