Method for the preparation of diols
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United States of America Patent
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Sep 1, 2015
Grant Date -
Dec 1, 2011
app pub date -
Jun 27, 2011
filing date -
Dec 31, 2008
priority date (Note) -
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Abstract
The present invention concerns a new method for the biological preparation of a diol comprising culturing a microorganism genetically modified for the bioproduction of an aliphatic diol, wherein the microorganism comprises a metabolic pathway for the decarboxylation of a hydroxy-2-keto-aliphatic acid metabolite with an enzyme having a 2-keto acid decarboxylase activity, the product obtained from said decarboxylation step being further reduced into the corresponding aliphatic diol, and wherein the microorganism is genetically modified for the improved production of said hydroxy-2-keto-aliphatic acid metabolite.
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