Process for preparing FGF21 with low degree of O-glycosylation
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United States of America Patent
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Sep 1, 2015
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Jan 3, 2013
app pub date -
Jan 20, 2011
filing date -
Jan 23, 2009
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Abstract
Expression of FGF21 in a S. cerevisiae pmt2 knock out strain reduces the O-glycosylation significantly and does not decrease the expression level. Expression in mkc7 knock out strain can decrease degradation of FGF21 and analogues thereof. Point mutations at position R17 and R36 can decrease degradation of FGF21 and analogues thereof when they are expressed in yeast.
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