Anti-CD19 antibody having ADCC function with improved glycosylation profile

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United States of America Patent

PATENT NO 9120856
APP PUB NO 20130183306A1
SERIAL NO

13811159

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Abstract

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The present invention relates to an anti-CD19 antibody having a variant Fc region having some specific amino acid modifications relative to a wild-type Fc region which confer one or several useful effector functions. The present invention relates in particular to chimeric, humanized or full human anti-CD19 antibodies comprising such a variant Fc region. It relates advantageously to antibodies with an interesting and valuable glycosylation profile, especially a low fucose level and/or a high oligomannose level and low level of sialic acid, high ADCC function and no CDC. The present invention also relates to the use of these antibodies in the treatment, prevention or management of diseases or disorders, such as cancer, especially a B-cell malignancy and auto-immune disease.

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Patent Owner(s)

Patent OwnerAddress
HOSPICES CIVILS DE LYON69229 LYON CEDEX 02
INTERNATIONAL-DRUG-DEVELOPMENT BIOTECH27 CHEMIN DES PEUPLIERS F-69570 DARDILLY
UCBL UNIVERSITE CLAUDE BERNARD DE LYON 143 BOULEVARD DU 11 NOVEMBRE 1918 69622 VILLEURBRANNE CEDEX

International Classification(s)

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  • 2011 Application Filing Year
  • C07K Class
  • 3299 Applications Filed
  • 2084 Patents Issued To-Date
  • 63.18 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2011201220132014201520162017201820192020202120220255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Salles, Gilles Sainte-Foy-les-Lyon, FR 1 2
Vermot-Desroches, Claudine Dardilly, FR 10 37

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Patent Citation Ranking

  • 2 Citation Count
  • C07K Class
  • 42.08 % this patent is cited more than
  • 10 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges1102126416145211432132101 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +010020030040050060070080090010001100120013001400

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11.5 Year Payment $7400.00 $3700.00 $1850.00 Mar 1, 2027