Saccharide conjugates
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United States of America Patent
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Sep 1, 2015
Grant Date -
Mar 6, 2014
app pub date -
Apr 18, 2012
filing date -
Apr 18, 2011
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Abstract
The invention provides a series of novel Lipid A analogs that are structually simple, synthetically accessible, and capable of blocking the cellular receptor within the signal transduction pathway. The novel Lipid A analogs can include a monosaccharide core with hydrophobic side chains and amino acid ionic motif. The invention further provides methods of using the compounds and compositions thereof in various therapeutic methods.
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