Method for the treatment of neurological disorders by enhancing the activity of beta-glucocerebrosidase
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United States of America Patent
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Sep 1, 2015
Grant Date -
Mar 3, 2011
app pub date -
Nov 8, 2010
filing date -
Jun 23, 2006
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Abstract
Provided is a method of increasing the stability of wild-type β-glucocerebrosidase. Also provided are methods of treating and/or preventing an individual having a neurological disease in which increased expression or activity of β-glucocerebrosidase in the central nervous system would be beneficial. This method includes administering an effective amount of a pharmacologic chaperone for β-glucocerebrosidase, with the proviso that the individual does not have a mutation in the gene encoding β-glucocerebrosidase. Further provided are β-glucocerebrosidase inhibitors which have been identified as specific pharmacologic chaperones and which have been shown to increase activity of β-glucocerebrosidase in vivo in the central nervous system.
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