Method for prevention or treatment of diabetic angiogenesis impairment using C-peptide
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United States of America Patent
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Sep 1, 2015
Grant Date -
May 8, 2014
app pub date -
Aug 6, 2013
filing date -
Aug 6, 2012
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Abstract
Disclosed are a method and composition for the prevention or treatment of diabetic angiogenesis impairment or diabetic wound-healing impairment, using C-peptide. Found to be able to induce angiogenesis through chemotactic migration of endothelial cells, cell migration to wounded areas, capillary-like network formation, and extracellular signal-regulated kinases 1/2 and Akt phosphorylation and nitric oxide production, C-peptide has prophylactic or therapeutic applications in a broad spectrum of various diabetic complications including diabetic angiogenesis impairment.
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