Method for detecting gene modifications by means of asymmetrical PCR and blocking agents

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United States of America Patent

PATENT NO 9115392
APP PUB NO 20120244538A1
SERIAL NO

13498699

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Abstract

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A method of detecting at least one gene modification such as a mutation in a gene includes carrying out an asymmetric polymerase chain reaction (PCR) with a combined use of at least one detectable mutation-specific hybridization probe (sensor probe) and at least one wild-type specific blocking agent which inhibits a binding of the at least one detectable mutation-specific hybridization probe (sensor probe) to a wild-type gene so as to provide at least one of a selective intensification and an amplification of a detection of a gene segment of a mutation gene having a gene modification.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITAET DUISBURG-ESSENUNIVERSITAETSSTRASSE 2 ESSEN 45141

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Breitenbuecher, Frank Muelheim an der Ruhr, DE 2 0
Hoffarth, Sandra Muelheim an der Ruhr, DE 2 0
Schuler, Martin Essen, DE 8 119
Stergar, Sarah-Luise Gelsenkirchen, DE 1 0

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