Method of increasing the productivity of eucaryotic cells in the production of recombinant FVIII

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United States of America Patent

PATENT NO 9115381
SERIAL NO

14113923

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A method of increasing productivity, in particularly cell-specific productivity, of recombinant factor VIII (rFVIII) produced in a eukaryotic cell suspension during culturing of the eucaryotic cell suspension in a culturing medium containing not more than 500 μM CaCl2, at least a non-ionic detergent and other nutrient components needed for the cells to grow and produce rFVIII, the cell suspension is cultured under conditions inducing a shear stress mechanically to the eucaryotic cell suspension by adding a power density of at least 3 W/m3.

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Patent Owner(s)

Patent OwnerAddress
OCTAPHARMA AG8853 LACHEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agerkvist, Irene Danderyd, SE 5 7
Aizawa, Peter Johannesshov, SE 1 0

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