Block copolymer having phenylboronic acid group introduced therein, and use thereof
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United States of America Patent
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Aug 25, 2015
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Feb 19, 2015
app pub date -
Nov 19, 2012
filing date -
Nov 17, 2011
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Abstract
A block copolymer includes a polyamino acid chain segment and a hydrophilic polymer chain segment. The polyamino acid chain segment includes at least one amino acid residue having a side chain that contains a cationic group and at least one amino acid residue having a side chain that contains a substituted phenylboronic acid group. In the substituted phenylboronic acid group, at least one hydrogen of the phenyl ring is substituted so that the phenylboronic acid group has a pKa of less than 8. Such a block copolymer serves as a carrier that simultaneously imparts stability to a biotechnology-based drug in blood and provides suitable drug-releasing properties of the drug at an affected area.
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