Methods for generating and screening fusion protein libraries and uses thereof
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United States of America Patent
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Aug 18, 2015
Grant Date -
Mar 19, 2009
app pub date -
Dec 22, 2006
filing date -
Dec 23, 2005
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Abstract
The invention provides methods for generating fusion protein libraries, such as immunotoxin libraries. The invention also relates to libraries of recombinant cells encoding nucleic acid sequences comprising fusion proteins. In addition, the invention relates to the libraries themselves and the use of the libraries to screen for fusion proteins that are specific for target cells, such as cancer cells. Further, the invention relates to methods of improving fusion proteins and to the improved fusion proteins.
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