MicroRNA as a cancer progression predictor and its use for treating cancer
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United States of America Patent
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Aug 18, 2015
Grant Date -
May 2, 2013
app pub date -
Dec 21, 2012
filing date -
Mar 29, 2011
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Abstract
The present invention is based on the findings that a novel function for miR142-3p in the regulation of Sox2, adenylyl cyclase 9 (AC9), and CD133 expressions, and consequently the overall stemness of recurrent GBM cells as well as CSCs, and that miR142-3p modulated tumor-initiating properties in recurrent GBM. The present invention consequently supports the development of novel miRNA-based strategies for brain tumor treatment.
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