Small diameter vascular graft produced by a hybrid method
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United States of America Patent
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Aug 18, 2015
Grant Date -
Jan 17, 2013
app pub date -
Nov 24, 2010
filing date -
Nov 25, 2009
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Abstract
The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a micropattern of grooves to which cells adhere and orient along. The exterior surface comprises electrospun microfibers wherein the microfibers provide mechanical properties to the graft. The hybrid graft is capable supporting endothelial cell attachment, endothelial cell alignment, cell proliferation, and maintaining their in vivo function. The graft of the invention can recapitulate the in vivo morphology and function of natural vascular endothelium.
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