Fused heterocyclic derivatives as S1P modulators

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United States of America Patent

PATENT NO 9096612
APP PUB NO 20140066433A1
SERIAL NO

14019236

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Abstract

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The present invention relates to a fused heterocyclic derivative of the formula (I) The variables R1-R4, z, A, Q, X and Y are as defined in the claims. The following heterocycles are exemplified sub-structures of formula (I): The compounds of formula (I) are modulators of the S1P receptor (Sphingosine-1-phosphate receptor), More specifically, they are agonists of S1P5. The compounds have therapeutic use in treatment of cognitive disorders, age-relate cognitive decline and dementia.

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Patent Owner(s)

  • ABBVIE B.V.;ABBVIE INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Coolen, Hein K A C Hoofddorp, NL 17 26
den, Hartog Jacobus A J Hoofddorp, NL 17 37
Hobson, Adrian Worcester, US 11 26
Iwema, Bakker Wouter I Hoofddorp, NL 21 59
Sliedregt, Leonardus A J M Hoofddorp, NL 4 7
Smid, Pieter Hoofddorp, NL 10 17
van, Dongen Maria J P Hoofddorp, NL 8 16

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