Triazole derivatives as Wnt signaling pathway inhibitors
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United States of America Patent
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Aug 4, 2015
Grant Date -
Jan 30, 2014
app pub date -
Dec 8, 2011
filing date -
Dec 8, 2010
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Abstract
The present invention relates to compounds of formula (I), to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy: Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway and increased presence of nuclear β-catenin. For example, these may be used in preventing and/or retarding proliferation of tumor cells and metastasis, for example carcinomas such as colon carcinomas.
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