Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate
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United States of America Patent
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Jul 21, 2015
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Jun 6, 2013
app pub date -
May 27, 2011
filing date -
May 27, 2010
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Abstract
The present invention discloses chemical synthesis, anti-tumor and anti-metastatic effects of a dual functional conjugate as shown by formula I. Specifically, paclitaxel or docetaxol is linked with muramyl dipeptide derivative to form a conjugate, thus dual anti-tumor and anti-metastatic effects are achieved by combination of chemotherapy and immunotherapy. The present invention also discloses that paclitaxel or docetaxol and muramyl dipeptide derivative conjugate is synthesized by combination of solid-phase and solution-phase synthesis, and said conjugate can be used in manufacture of anti-tumor medicaments as proved by reliable bioassays.
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