Methods of preparing icotinib and icotinib hydrochloride, and intermediates thereof
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United States of America Patent
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Jul 21, 2015
Grant Date -
Nov 20, 2014
app pub date -
Dec 28, 2012
filing date -
Oct 31, 2011
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Abstract
The present invention relates to the technical field of medicine, and specifically provides methods for preparing Icotinib, Icotinib hydrochloride, and intermediates thereof. These methods avoid the use of phosphorus oxychloride, thereby greatly reducing the emission of pollutants, which is of major benefits to the economy and environment.
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