Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
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United States of America Patent
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Jul 21, 2015
Grant Date -
Feb 20, 2014
app pub date -
Jul 25, 2011
filing date -
Jul 26, 2010
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Abstract
The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.
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