Culturing human embryonic stem cells with a noggin to generate cells lacking Pax-6 expression

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United States of America Patent

PATENT NO 9080147
APP PUB NO 20090197334A1
SERIAL NO

12363194

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Abstract

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The present invention provides a preparation of undifferentiated embryonic stem (ES) cells sustainable for a prolonged period in an undifferentiated state which will undergo stem cell renewal or somatic differentiation. Preferably the cells are capable of somatic differentiation in vitro and are inclined to differentiate away from an extraembryonic lineage. The present invention also provides method of culturing embryonic stem (ES) cells to improve stem cell maintenance and persistence in culture. The method also provides a culture of ES cells prepared by the method as well as differentiated cells derived from the embryonic cells resulting from directed differentiation procedures provided by the present invention.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL UNIVERSITY OF SINGAPORESINGAPORE SINGAPORE SINGAPORE CITY SINGAPORE
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTDJERUSALEM BIOPARK HADASSAH EIN KEREM MEDICAL CENTER P O BOX 12000 JERUSALEM 9112001
MONASH UNIVERSITYMANAGER INTELLECTUAL PROPERTY INDUSTRY ENGAGEMENT & COMMERCIALISATION BUILDING 75 CLAYTON CAMPUS VICTORIA 3180

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Pera, Martin Frederick Prahran, AU 18 330

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