Improving efficacy of cancer therapy

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United States of America Patent

PATENT NO 9078856
APP PUB NO 20130150432A1
SERIAL NO

13703765

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Abstract

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Embodiments of the invention provide a method of improving the efficacy of an anti-cancer therapy and a method of treatment of cancer by normalizing angiogenesis in cancer. By enhancing the cell signaling pathway via a TRPV4 receptor in tumor endothelial cells, either by a TRPV4 agonist or by increasing the expression of TRPV4 in the tumor endothelial cells, the tumor endothelial cells behave normally and form normal angiogenic network for better anti-cancer therapy to the tumors.

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Patent Owner(s)

Patent OwnerAddress
NORTHEAST OHIO MEDICAL UNIVERSITY4209 STATE ROUTE 44 PO BOX 95 ROOTSTOWN OH 44272

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ingber, Donald E Boston, US 200 3052
Thodeti, Charles K Copley, US 5 4

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