Photostabilized pharmaceutical compositions
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United States of America Patent
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Jul 7, 2015
Grant Date -
Oct 6, 2011
app pub date -
Sep 30, 2009
filing date -
Sep 30, 2008
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Abstract
A crosslinking reaction and a reaction for reducing molecular weight that take place in a hyaluronic acid-methotrexate conjugate upon irradiation with light are suppressed to improve the photostability of the conjugate. Specifically, a substance having a quenching effect and/or a radical scaveng effect is added to a pharmaceutical composition containing the hyaluronic acid-methotrexate conjugate.
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