Modified human tumor necrosis factor receptor-1 polypeptide or fragment thereof, and method for preparing same
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United States of America Patent
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Jun 30, 2015
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Oct 4, 2012
app pub date -
Oct 19, 2010
filing date -
Oct 19, 2009
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Abstract
The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide to be coupled to a tumor necrosis factor in vivo or ex vivo, or to a fragment thereof. The modified human tumor necrosis factor receptor-1 polypeptide or the fragment thereof according to the present invention exhibit improved resistance against in vivo protease activity, and thus exhibit improved bioavailability and an improved absorption rate.
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