Conjugates for the treatment of mesothelioma
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United States of America Patent
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Jun 30, 2015
Grant Date -
Nov 28, 2013
app pub date -
Jan 25, 2013
filing date -
May 13, 2008
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Abstract
The present invention provides conjugates of cytokines and targeting peptides that is able to bind to a receptor expressed on tumor-associated vessels or to a component of the extracellular matrix associated to the tumor vessels, for treatment of malignant pleural mesothelioma. In particular, the invention provides conjugates comprising the cytokine TNF linked to a peptide containing the NGR motif. The invention further provides pharmaceutical compositions comprising such conjugate and pharmaceutical formulations comprising conjugates dissolved in appropriate buffers.
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