Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
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United States of America Patent
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Jun 30, 2015
Grant Date -
Oct 25, 2012
app pub date -
Dec 22, 2010
filing date -
Dec 22, 2009
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Abstract
Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided.
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