Use of the effective fraction of alkaloids from mulberry twig in preparing hypoglycemic agents

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United States of America Patent

PATENT NO 9066960
APP PUB NO 20110130352A1
SERIAL NO

12674532

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Abstract

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The present invention relates to an effective fraction of alkaloids and the effective fraction is prepared from mulberry twig and its active ingredients are a composition of alkaloids. Determined by HPLC, the percentage of the total alkaloids are 50% or more by weight in the effective fraction and the percentage of the compound 1-deoxynojirimycin is 30% or more by weight in the total alkaloids. The effective fraction of the invention is prepared as the following steps: the mulberry twig is extracted by solvents, and the extract is precipitated by alcohol precipitation or flocculation to remove the impurities, and then concentrated, purified by resin chromatography. The present invention also relates to a pharmaceutical composition containing the said effective fraction of alkaloids and to the use of the effective fraction of alkaloids according to claim 1-4 in preparing hypoglycemic agents.

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Patent Owner(s)

Patent OwnerAddress
INSTITUTE OF MATARIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES100050 NO 1 XIANNONGTAN STREET XICHENG DISTRICT BEIJING BEIJING CITY BEIJING CITY 100050

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Yueteng Beijing, CN 1 4
Chen, Zhen Beijing, CN 228 1215
Liu, Quan Beijing, CN 92 458
Liu, Yuling Beijing, CN 23 57
Shen, Zhufang Beijing, CN 3 4
Sun, Sujuan Beijing, CN 3 5
Wang, Renyun Beijing, CN 5 12
Xia, Xuejun Beijing, CN 6 12
Xie, Mingzhi Beijing, CN 1 4

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