Cytokine biomarkers as predictive biomarkers of clinical response for glatiramer acetate
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United States of America Patent
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Jun 23, 2015
Grant Date -
Oct 2, 2014
app pub date -
Apr 11, 2014
filing date -
Oct 11, 2010
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Abstract
A method for treating a human subject afflicted with multiple sclerosis or a single clinical attack consistent with multiple sclerosis with a pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier, comprising the steps of determining whether the human subject is a glatiramer acetate responder by evaluating a biomarker selected from the group consisting of IL-17 concentration, TNF-α concentration, IL-2 concentration and IFN-γ concentration, or a combination thereof, in the blood of the human subject and administering the pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier to the human subject only if the human subject is identified as a glatiramer acetate responder.
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