Heparin binding epidermal growth factor (HB-EGF) for use in methods of treating and preventing intestinal injury related to hemorrhagic shock and resuscitation
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United States of America Patent
Stats
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Jun 23, 2015
Grant Date -
Jun 27, 2013
app pub date -
Jan 9, 2012
filing date -
Apr 30, 2007
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The invention is related to methods of protecting, preventing and reducing intestinal injury in a human subject suffering from or at risk for shock, hemorrhagic shock or hemorrhagic shock and resuscitation (HS/R) comprising administering heparin binding epidermal growth factor (HB-EGF). The invention is also related to methods of inhibiting deterioration of intestinal blood flow and methods of preserving and increasing intestinal blood flow by administering HB-EGF to a human subject. In addition, the methods of the invention should improve the clinical outcome of human subject suffering from or at risk for shock, hemorrhagic shock or hemorrhagic shock and resuscitation.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
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NATIONWIDE CHILDREN'S HOSPITAL INC | 700 CHILDREN'S DRIVE COLUMBUS OH 43205 |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
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Besner, Gail E | Dublin, US | 19 | 111 |
# of filed Patents : 19 Total Citations : 111 | |||
El-Assal, Osama N | Gahanna, US | 2 | 0 |
# of filed Patents : 2 Total Citations : 0 |
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Dec 23, 2026 |
Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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Legal Events
Date | Code | Event | Description |
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Jan 17, 2022 | STCH | INFORMATION ON STATUS: PATENT DISCONTINUATION | free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
Jan 17, 2022 | LAPS | LAPSE FOR FAILURE TO PAY MAINTENANCE FEES | free format text: PATENT EXPIRED FOR FAILURE TO PAY MAINTENANCE FEES (ORIGINAL EVENT CODE: EXP.); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
Dec 12, 2021 | FP | LAPSED DUE TO FAILURE TO PAY MAINTENANCE FEE | Effective Date: Dec 12, 2021 |
Aug 02, 2021 | FEPP | FEE PAYMENT PROCEDURE | free format text: MAINTENANCE FEE REMINDER MAILED (ORIGINAL EVENT CODE: REM.); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
Dec 12, 2017 | I | Issuance | |
Dec 12, 2017 | PD | Priority Date | |
Nov 21, 2017 | STCF | INFORMATION ON STATUS: PATENT GRANT | free format text: PATENTED CASE |
Nov 02, 2017 | P | Published | |
Apr 10, 2017 | AS | ASSIGNMENT | free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HU, XING;ZHOU, GUIHONG;ZHANG, WEI;AND OTHERS;REEL/FRAME:042155/0433 Owner name: GRG BANKING EQUIPMENT CO., LTD., CHINA Effective Date: Apr 10, 2017 |
Aug 07, 2015 | F | Filing |

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