Infectious hepatitis C virus—high producing HCV variants and use thereof
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United States of America Patent
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Jun 16, 2015
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Mar 28, 2013
app pub date -
Mar 25, 2011
filing date -
Mar 25, 2010
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Abstract
An objective of this invention is to provide an HCV strain with a high capacity for virus production in a cell culture system. This invention provides a nucleic acid encoding a polyprotein precursor of the hepatitis C virus JFH1 strain having one or more amino acid substitutions, wherein the polyprotein precursor comprises at least substitution of glutamine at position 862 with arginine, as determined with reference to the amino acid sequence as shown in SEQ ID NO: 2 in the Sequence Listing.
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