Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
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Jun 16, 2015
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Apr 10, 2008
app pub date -
Oct 6, 2006
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Oct 6, 2006
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Abstract
The present invention incorporates weakly basic substituents (pKa about 8 or greater) such as pyrrolidine, piperidine, piperazine and azapane moieties in halogenated 2-nitromidazoles for the non-invasive detection of cellular hypoxia in normal and malignant tissues. The compounds of the invention can be used in 18F positron emission tomography, 19F magnetic resonance spectroscopy, and 19F magnetic resonance imaging.
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