Malt1 specific cleavage in assay and screening method
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United States of America Patent
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Jun 9, 2015
Grant Date -
Jul 22, 2010
app pub date -
May 30, 2008
filing date -
Jun 1, 2007
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Abstract
The present invention is based on the surprising finding of a proteolytic cleavage function of human Malt1. More particularly, the present invention relates to enzyme and screening assays, methods for assessing cleaving activity, methods for screening, isolated polypeptides, antibodies and inhibitors of Malt1. The present invention also relates to the use of Malt1 as a proteolytic enzyme and the use of compounds comprising a peptide comprising an amino acid sequence according to any one of SEQ ID NO: 1-47 as substrates susceptible for specific proteolytic cleavage.
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